Question

A 56‑year‑old man with a first episode of non‑severe Clostridioides difficile infection (WBC 12,000/µL, creatinine at baseline, ≥3 loose stools/day) asks about treatment. Best initial therapy?

Accepted Answer

Fidaxomicin 200 mg orally twice daily for 10 days

Answer

Metronidazole 500 mg orally three times daily for 10 days

Answer

Vancomycin 125 mg orally four times daily plus metronidazole IV

Answer

Probiotics alone with hydration

Answer

Bezlotoxumab infusion as monotherapy

Practice question

A 56‑year‑old man with a first episode of non‑severe Clostridioides difficile infection (WBC 12,000/µL, creatinine at baseline, ≥3 loose stools/day) asks about treatment. Best initial therapy?