A 25-year-old man with recent condomless receptive anal intercourse presents 30 hours after exposure to a partner of unknown HIV status. Baseline HIV ...

Question

A 25-year-old man with recent condomless receptive anal intercourse presents 30 hours after exposure to a partner of unknown HIV status. Baseline HIV Ag/Ab is pending. Best next step per current US nPEP guidance?

Accepted Answer

Initiate a 28‑day antiretroviral PEP regimen immediately (e.g.

Answer

bictegravir/FTC/TAF or DTG + TDF/FTC)

Answer

Wait for baseline HIV test before starting PEP

Answer

Start PEP only if source later tests HIV positive

Answer

Give 7 days of PEP and stop if source is negative

CDC (2025): Antiretroviral Postexposure Prophylaxis After Sexual Exposure MCQ (SBA): HIV Post-Exposure Prophyl

A 25-year-old man with recent condomless receptive anal intercourse presents 30 hours after exposure to a partner of unknown HIV status. Baseline HIV Ag/Ab is pending. Best next step per current US nPEP guidance?