A 59-year-old with severe C. difficile infection (WBC 18,000/µL, creatinine 1.8 mg/dL) has first episode. Best initial therapy?...

Question

A 59-year-old with severe C. difficile infection (WBC 18,000/µL, creatinine 1.8 mg/dL) has first episode. Best initial therapy?

Accepted Answer

Fidaxomicin 200 mg PO twice daily for 10 days

Answer

No antibiotics; observe

Answer

Fecal microbiota transplantation as first-line

Answer

Metronidazole 500 mg PO TID alone

Answer

Vancomycin 125 mg PO once daily

IDSA/SHEA focused update (2021): Clostridioides difficile infection MCQ (SBA): Clostridioides difficile infect