Question

A 48-year-old with COPD on LABA/LAMA has two moderate exacerbations in the past year. Blood eosinophil count is 350 cells/µL. What is the next best pharmacologic step?

Accepted Answer

Escalate to triple therapy (LABA/LAMA/ICS)

Answer

Switch to ICS monotherapy

Answer

Add roflumilast now instead of inhaled corticosteroid

Answer

Continue LABA/LAMA without change

Answer

Add chronic oral prednisone 5 mg daily

Practice question

A 48-year-old with COPD on LABA/LAMA has two moderate exacerbations in the past year. Blood eosinophil count is 350 cells/µL. What is the next best pharmacologic step?