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MediumADA recommends initiating insulin in patients with significant hyperglycaemia (e.g. A1C ≥10%) and symptomatic catabolism. Oral monotherapy is insufficient; delaying therapy risks further metabolic decompensation.ADA Standards of Care (2025): Pharmacologic Approaches to Glycemic Treatmentendocrinology

A 60-year-old with A1C 10.8% has polyuria, and ketonemia absent DKA. What initial therapy is indicated per ADA?

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