Question

A 54-year-old with recurrent gout flares (≥2/year), tophi on exam, and serum urate 9.2 mg/dL has eGFR 60. Best long-term urate-lowering strategy?

Accepted Answer

Start allopurinol ≤100 mg daily and titrate to target <6 mg/dL with flare prophylaxis

Answer

Probenecid as first-line ULT

Answer

Start febuxostat 120 mg daily immediately

Answer

Colchicine PRN without ULT

Answer

High-dose vitamin C supplementation

Practice question

A 54-year-old with recurrent gout flares (≥2/year), tophi on exam, and serum urate 9.2 mg/dL has eGFR 60. Best long-term urate-lowering strategy?