Question

A 72-year-old with atrial fibrillation and CKD eGFR 22 mL/min takes apixaban 5 mg BID. Which dose adjustment is appropriate based on renal function alone?

Accepted Answer

Continue 5 mg BID unless ≥2 of: age ≥80, weight ≤60 kg, or creatinine ≥1.5 mg/dL

Answer

Reduce to 2.5 mg BID solely for eGFR 22

Answer

Stop apixaban and switch to warfarin for all CKD

Answer

Once-daily dosing

Answer

Hold therapy until eGFR >30

Practice question

A 72-year-old with atrial fibrillation and CKD eGFR 22 mL/min takes apixaban 5 mg BID. Which dose adjustment is appropriate based on renal function alone?