Question

A 57-year-old hospitalized adult has a first episode of nonsevere Clostridioides difficile infection (WBC 13,000/µL, creatinine 0.9 mg/dL). Best initial therapy?

Accepted Answer

Fidaxomicin 200 mg orally twice daily for 10 days

Answer

Metronidazole 500 mg orally three times daily for 10 days

Answer

Bezlotoxumab single IV dose plus metronidazole

Answer

Vancomycin 125 mg orally four times daily for 10 days

Answer

Probiotics alone

Practice question

A 57-year-old hospitalized adult has a first episode of nonsevere Clostridioides difficile infection (WBC 13,000/µL, creatinine 0.9 mg/dL). Best initial therapy?