Question

A 74-year-old ICU patient with hypotension, fever, ileus, WBC 24,000/µL, creatinine 2.0 mg/dL, and profuse diarrhea tests positive for C. difficile. Best antibiotic regimen?

Accepted Answer

High-dose oral vancomycin 500 mg four times daily plus IV metronidazole 500 mg every 8 hours

Answer

Fidaxomicin 200 mg twice daily alone

Answer

Vancomycin 125 mg four times daily alone

Answer

Metronidazole 500 mg IV three times daily alone

Answer

Oral rifaximin

Practice question

A 74-year-old ICU patient with hypotension, fever, ileus, WBC 24,000/µL, creatinine 2.0 mg/dL, and profuse diarrhea tests positive for C. difficile. Best antibiotic regimen?