Question

A 49-year-old with recurrent gout flares (≥3/year), serum urate 9.2 mg/dL, and normal renal function is between flares. What is the best next step?

Accepted Answer

Start allopurinol 100 mg daily and titrate to serum urate <6 mg/dL

Answer

Begin probenecid mono­therapy

Answer

Use intermittent colchicine only during flares

Answer

Start febuxostat only if HLA-B*58:01 negative

Answer

Defer urate-lowering therapy until tophi appear

Practice question

A 49-year-old with recurrent gout flares (≥3/year), serum urate 9.2 mg/dL, and normal renal function is between flares. What is the best next step?