A healthcare worker presents 24 hours after a high-risk occupational needle-stick from a source with unknown HIV status. HIV test is negative today. B...

Question

A healthcare worker presents 24 hours after a high-risk occupational needle-stick from a source with unknown HIV status. HIV test is negative today. Best management?

Accepted Answer

Start three-drug PEP for 28 days (e.g., TDF/FTC plus dolutegravir)

Answer

No PEP; repeat HIV test in 6 weeks

Answer

Two-drug PEP for 7 days

Answer

Start PrEP instead of PEP

Answer

Wait for source testing before treatment

us-usmle-step-2 MCQ (SBA): HIV PEP

A healthcare worker presents 24 hours after a high-risk occupational needle-stick from a source with unknown HIV status. HIV test is negative today. Best management?