Question

A 59-year-old with an initial episode of non-severe Clostridioides difficile infection (≥3 unformed stools/day; WBC 9,800/µL; creatinine normal) has no contraindications to oral therapy. Best initial treatment?

Accepted Answer

Fidaxomicin 200 mg PO BID for 10 days

Answer

Metronidazole 500 mg PO TID for 14 days

Answer

Vancomycin 125 mg PO QID for 10 days is inferior and not recommended

Answer

Fecal microbiota transplant as first-line

Answer

Bezlotoxumab monotherapy

Practice question

A 59-year-old with an initial episode of non-severe Clostridioides difficile infection (≥3 unformed stools/day; WBC 9,800/µL; creatinine normal) has no contraindications to oral therapy. Best initial treatment?