Question

A 46-year-old man with gout has ≥2 flares/year and tophus on exam; eGFR 55. Best urate-lowering therapy strategy?

Accepted Answer

Start allopurinol at low dose and titrate to serum urate <6 mg/dL

Answer

Probenecid first-line in CKD

Answer

Defer ULT until flares cease for a year

Answer

Febuxostat first-line in all patients

Answer

Aim for urate <8 mg/dL

Practice question

A 46-year-old man with gout has ≥2 flares/year and tophus on exam; eGFR 55. Best urate-lowering therapy strategy?