A 48-year-old with first episode of nonsevere Clostridioides difficile infection (WBC 11,000/µL, creatinine normal). Best initial therapy?...

Question

A 48-year-old with first episode of nonsevere Clostridioides difficile infection (WBC 11,000/µL, creatinine normal). Best initial therapy?

Accepted Answer

Fidaxomicin 200 mg twice daily for 10 days.

Answer

Metronidazole 500 mg TID for 10 days as first-line.

Answer

Oral vancomycin 125 mg QID for 10 days is preferred to all others.

Answer

Fecal microbiota therapy.

Answer

Probiotics only.

us-usmle-step-2 MCQ (SBA): Clostridioides difficile Infection