Question

An adult with a first episode of non-severe Clostridioides difficile infection (WBC 11,000 per mm³, creatinine 1.0 mg/dL) presents with watery diarrhea and abdominal cramps. Best initial therapy?

Accepted Answer

Fidaxomicin 200 mg orally twice daily for 10 days

Answer

Metronidazole 500 mg orally three times daily for 10 days

Answer

Probiotics alone

Answer

Vancomycin 125 mg orally four times daily for 3 days then stop

Answer

No antibiotics; hydration only

Practice question

An adult with a first episode of non-severe Clostridioides difficile infection (WBC 11,000 per mm³, creatinine 1.0 mg/dL) presents with watery diarrhea and abdominal cramps. Best initial therapy?