Question

A 73-year-old with severe COPD exacerbation needs IV gentamicin for concomitant sepsis and has eGFR 40. What principle guides dosing?

Accepted Answer

Use adjusted body weight if obese and extend interval based on renal function with therapeutic drug monitoring

Answer

Dose by total body weight only

Answer

Use standard once-daily dose regardless of renal function

Answer

Avoid all aminoglycosides in CKD

Answer

Give continuous infusion

Practice question

A 73-year-old with severe COPD exacerbation needs IV gentamicin for concomitant sepsis and has eGFR 40. What principle guides dosing?