A 74-year-old woman has been taking Methotrexate 15mg once weekly for rheumatoid arthritis for the past year, along with Folic Acid 5mg once weekly. S...

Question

A 74-year-old woman has been taking Methotrexate 15mg once weekly for rheumatoid arthritis for the past year, along with Folic Acid 5mg once weekly. She presents with increasing fatigue and shortness of breath on exertion. FBC shows: Hb 105 g/L, MCV 108 fL (80-100), WCC 4.5 x10^9/L, Platelets 150 x10^9/L. What is the most likely cause of her macrocytic anaemia?

Accepted Answer

Folate deficiency secondary to Methotrexate

Answer

Iron deficiency anaemia

Answer

Vitamin B12 deficiency

Answer

Anaemia of chronic disease

Answer

Myelodysplastic syndrome

ukmla MCQ (SBA): Macrocytic Anaemia (Drug-induced)