A 71-year-old on warfarin (target INR 2.5) for AF presents with new fluconazole for candidiasis. What is the expected interaction and action?...

Question

A 71-year-old on warfarin (target INR 2.5) for AF presents with new fluconazole for candidiasis. What is the expected interaction and action?

Accepted Answer

Fluconazole increases INR; monitor and reduce warfarin dose

Answer

No interaction; continue as usual

Answer

Fluconazole reduces INR; increase warfarin dose

Answer

Fluconazole increases INR; stop apixaban

Answer

Switch to dabigatran immediately

prescribing safety assessment MCQ (SBA): Warfarin–fluconazole interaction