A 56-year-old with chronic hepatitis C is starting direct-acting antivirals. Which PPI management is important with ledipasvir/sofosbuvir?...

Question

A 56-year-old with chronic hepatitis C is starting direct-acting antivirals. Which PPI management is important with ledipasvir/sofosbuvir?

Accepted Answer

Avoid PPIs or separate/lowest dose

Answer

Increase PPI dose

Answer

Take PPI and DAAs together with food

Answer

Switch to H2-blocker at high dose

Answer

No interaction

prescribing safety assessment MCQ (SBA): DAA–PPI interaction