A 72-year-old woman is taking Apixaban 5mg BD for atrial fibrillation. She has a history of CKD stage 3b (eGFR 35 mL/min/1.73m²). She is commenced on ...

Question

A 72-year-old woman is taking Apixaban 5mg BD for atrial fibrillation. She has a history of CKD stage 3b (eGFR 35 mL/min/1.73m²). She is commenced on Clarithromycin for a lower respiratory tract infection. What is the most appropriate action regarding her anticoagulation?

Accepted Answer

Reduce Apixaban dose to 2.5mg BD temporarily

Answer

Stop Apixaban during the antibiotic course

Answer

Switch Apixaban to Warfarin

Answer

Continue Apixaban 5mg BD with close monitoring

Answer

Switch Apixaban to Dabigatran

mrcgp akt MCQ (SBA): Drug Interactions

A 72-year-old woman is taking Apixaban 5mg BD for atrial fibrillation. She has a history of CKD stage 3b (eGFR 35 mL/min/1.73m²). She is commenced on Clarithromycin for a lower respiratory tract infection. What is the most appropriate action regarding her anticoagulation?