A 30-year-old woman presents with Raynaud's phenomenon, difficulty swallowing (dysphagia), and skin tightening over her fingers (sclerodactyly). Blood...

Question

A 30-year-old woman presents with Raynaud's phenomenon, difficulty swallowing (dysphagia), and skin tightening over her fingers (sclerodactyly). Blood tests show a positive ANA. Which specific autoantibody is most strongly associated with this presentation?

Accepted Answer

Anti-centromere antibodies

Answer

Anti-Jo-1 antibodies

Answer

Anti-Ro/La antibodies

Answer

Anti-Scl-70 (topoisomerase I) antibodies

Answer

Anti-smooth muscle antibodies

mrcp part 1 MCQ (SBA): Systemic Sclerosis (Limited Cutaneous)

A 30-year-old woman presents with Raynaud's phenomenon, difficulty swallowing (dysphagia), and skin tightening over her fingers (sclerodactyly). Blood tests show a positive ANA. Which specific autoantibody is most strongly associated with this presentation?