Question

A 45-year-old woman presents with fatigue, weight loss, dizziness, and hyperpigmentation of the palmar creases. BP is 90/60 mmHg. Bloods show Na+ 130 mmol/L, K+ 5.8 mmol/L. A random cortisol is 100 nmol/L. What is the most appropriate diagnostic investigation to confirm the suspected diagnosis?

Accepted Answer

Short Synacthen Test (ACTH stimulation test)

Answer

24-hour urinary cortisol

Answer

Dexamethasone suppression test

Answer

Plasma renin and aldosterone levels

Answer

MRI adrenal glands

Practice question

A 45-year-old woman presents with fatigue, weight loss, dizziness, and hyperpigmentation of the palmar creases. BP is 90/60 mmHg. Bloods show Na+ 130 mmol/L, K+ 5.8 mmol/L. A random cortisol is 100 nmol/L. What is the most appropriate diagnostic investigation to confirm the suspected diagnosis?