Question

A 75-year-old man is taking Apixaban 5mg BD for AF. He is admitted with a major upper GI bleed and is haemodynamically unstable (BP 80/50 mmHg). Resuscitation is ongoing. What is the most appropriate management regarding anticoagulation reversal?

Accepted Answer

Administer Andexanet Alfa

Answer

Administer Vitamin K 10mg IV

Answer

Administer Prothrombin Complex Concentrate (PCC)

Answer

Stop Apixaban and monitor only

Answer

Administer Fresh Frozen Plasma (FFP)

Practice question

A 75-year-old man is taking Apixaban 5mg BD for AF. He is admitted with a major upper GI bleed and is haemodynamically unstable (BP 80/50 mmHg). Resuscitation is ongoing. What is the most appropriate management regarding anticoagulation reversal?