A 16-year-old girl presents with moderate acne vulgaris (inflammatory papules and pustules). She has tried over-the-counter benzoyl peroxide with minimal improvement. What is the most appropriate next step in management according to NICE guidelines?AOral IsotretinoinBA fixed combination of topical adapalene and topical benzoyl peroxideCOral contraceptive pill (e.g., Co-cyprindiol)DOral antibiotic (e.g., Lymecycline)ETopical azelaic acid monotherapyCheck my answer