A 10-year-old child presents with recurrent chest infections, pancreatic insufficiency, and failure to thrive. A sweat test shows elevated chloride le...

Question

A 10-year-old child presents with recurrent chest infections, pancreatic insufficiency, and failure to thrive. A sweat test shows elevated chloride levels. What is the underlying pathophysiology?

Accepted Answer

Defective chloride channels (CFTR) in epithelial cells

Answer

Excess chloride reabsorption in sweat glands

Answer

Overproduction of mucus by hypertrophic goblet cells

Answer

Primary immunodeficiency affecting lung defences

Answer

Autoimmune destruction of pancreatic acinar cells

pane MCQ (SBA): Cystic Fibrosis

A 10-year-old child presents with recurrent chest infections, pancreatic insufficiency, and failure to thrive. A sweat test shows elevated chloride levels. What is the underlying pathophysiology?