Question

A 55-year-old woman is diagnosed with rheumatoid arthritis. She has active synovitis in multiple small joints of her hands and feet, and her DAS28 score is 5.5. According to NICE guidelines, what is the most appropriate initial approach to disease-modifying anti-rheumatic drug (DMARD) therapy?

Accepted Answer

Combination therapy with methotrexate and another DMARD (e.g., sulfasalazine) plus short-term bridging corticosteroids

Answer

Methotrexate monotherapy

Answer

Sulfasalazine monotherapy

Answer

Hydroxychloroquine monotherapy

Answer

Leflunomide monotherapy

Practice question

A 55-year-old woman is diagnosed with rheumatoid arthritis. She has active synovitis in multiple small joints of her hands and feet, and her DAS28 score is 5.5. According to NICE guidelines, what is the most appropriate initial approach to disease-modifying anti-rheumatic drug (DMARD) therapy?