A 33-year-old man presents with a 2-week history of bloody diarrhoea, abdominal cramps, and urgency. He is opening his bowels 8-10 times per day. Flex...

Question

A 33-year-old man presents with a 2-week history of bloody diarrhoea, abdominal cramps, and urgency. He is opening his bowels 8-10 times per day. Flexible sigmoidoscopy reveals continuous inflammation with loss of vascular pattern, contact bleeding, and ulceration extending from the rectum to the sigmoid colon. Biopsies confirm active chronic colitis. What is the most appropriate initial treatment to induce remission according to NICE guidelines?

Accepted Answer

Oral prednisolone

Answer

Oral mesalazine (5-ASA)

Answer

Topical mesalazine (suppository or enema)

Answer

Oral azathioprine

Answer

Infliximab infusion

ukmla MCQ (SBA): Ulcerative Colitis (Moderate-Severe)