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MediumPharmacologyDrug Interaction (Methotrexate/Trimethoprim)ukmlamrcgp aktpanemrcp part 1prescribing safety assessment

A 50-year-old patient with rheumatoid arthritis, well-controlled on methotrexate 15mg weekly and folic acid 5mg weekly, requires treatment for an infection. Which antibiotic should generally be avoided due to a significant interaction with methotrexate, increasing the risk of methotrexate toxicity (e.g., myelosuppression)?

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