Question

A 68-year-old woman with rheumatoid arthritis, treated with methotrexate 15mg weekly and folic acid 5mg weekly (on a different day), presents for routine blood monitoring. Which blood test abnormality is most specifically associated with methotrexate toxicity?

Accepted Answer

Neutropenia

Answer

Raised ALT

Answer

Macrocytosis (Raised MCV)

Answer

Thrombocytosis

Answer

Hypokalaemia

Practice question

A 68-year-old woman with rheumatoid arthritis, treated with methotrexate 15mg weekly and folic acid 5mg weekly (on a different day), presents for routine blood monitoring. Which blood test abnormality is most specifically associated with methotrexate toxicity?