A 65-year-old woman with rheumatoid arthritis, treated with methotrexate 15mg once weekly and folic acid 5mg once weekly, presents for routine blood m...

Question

A 65-year-old woman with rheumatoid arthritis, treated with methotrexate 15mg once weekly and folic acid 5mg once weekly, presents for routine blood monitoring. Which of the following results would necessitate immediately stopping methotrexate and seeking urgent specialist advice?

Accepted Answer

WBC 3.0 x 10^9/L (Normal 4.0-11.0)

Answer

ALT 80 U/L (Normal

Answer

Platelets 130 x 10^9/L (Normal 150-400)

Answer

MCV 105 fL (Normal 80-100)

Answer

Serum Creatinine 110 µmol/L (Previously 90)

ukmla MCQ (SBA): Methotrexate Monitoring / Toxicity

A 65-year-old woman with rheumatoid arthritis, treated with methotrexate 15mg once weekly and folic acid 5mg once weekly, presents for routine blood monitoring. Which of the following results would necessitate immediately stopping methotrexate and seeking urgent specialist advice?