Question

A 77-year-old man with Parkinson's disease, treated with co-careldopa, experiences worsening motor fluctuations and troublesome dyskinesias. Which medication class, when added, is most likely to improve motor fluctuations but has a high risk of worsening or causing dyskinesias?

Accepted Answer

Levodopa dose increase

Answer

MAO-B inhibitor (e.g., rasagiline)

Answer

COMT inhibitor (e.g., entacapone)

Answer

Dopamine agonist (e.g., ropinirole)

Answer

Amantadine

Practice question

A 77-year-old man with Parkinson's disease, treated with co-careldopa, experiences worsening motor fluctuations and troublesome dyskinesias. Which medication class, when added, is most likely to improve motor fluctuations but has a high risk of worsening or causing dyskinesias?