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MediumPsychiatryDementia with Behavioural Disturbanceukmlamrcgp aktpaneprescribing safety assessment

A 70-year-old woman with moderate Alzheimer's disease, currently treated with Donepezil, has developed significant agitation and verbal aggression over the past month, causing distress to herself and her carers. Non-pharmacological strategies (e.g., environmental modification, activity scheduling) have been trialled unsuccessfully. If pharmacological treatment is deemed necessary after specialist advice, which medication is generally recommended first-line by NICE for short-term use in this situation?

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