Question

A 55-year-old man with Rheumatoid Arthritis (RA), treated with weekly Methotrexate, attends for routine blood monitoring. Results show: Hb 105 g/L, MCV 108 fL, WCC 3.5 x10^9/L, Platelets 130 x10^9/L. Liver function tests are normal. What is the most likely cause of the macrocytosis (raised MCV)?

Accepted Answer

Methotrexate-induced folate deficiency

Answer

Iron deficiency anaemia

Answer

Vitamin B12 deficiency

Answer

Alcohol excess

Answer

Underlying inflammatory process of RA

Practice question

A 55-year-old man with Rheumatoid Arthritis (RA), treated with weekly Methotrexate, attends for routine blood monitoring. Results show: Hb 105 g/L, MCV 108 fL, WCC 3.5 x10^9/L, Platelets 130 x10^9/L. Liver function tests are normal. What is the most likely cause of the macrocytosis (raised MCV)?