Question

A 58-year-old man with Parkinson's disease experiences end-of-dose 'wearing off' on his current levodopa regimen. According to NICE guidelines, which add-on therapy can help manage these motor fluctuations?

Accepted Answer

COMT inhibitor (e.g., entacapone)

Answer

Apomorphine infusion

Answer

Amantadine

Answer

MAO-B inhibitor (e.g., selegiline)

Answer

Anticholinergic (e.g., trihexyphenidyl)

Practice question

A 58-year-old man with Parkinson's disease experiences end-of-dose 'wearing off' on his current levodopa regimen. According to NICE guidelines, which add-on therapy can help manage these motor fluctuations?