Question

A 64-year-old man with known epilepsy is admitted for surgery. He has been well-controlled on sodium valproate. According to NICE guidelines, which drug interaction is a key concern when co-prescribing sodium valproate?

Accepted Answer

Increased risk of toxicity with lamotrigine

Answer

Reduced efficacy of clopidogrel

Answer

Increased clearance of warfarin

Answer

Reduced absorption of penicillin

Answer

Antagonism with digoxin

Practice question

A 64-year-old man with known epilepsy is admitted for surgery. He has been well-controlled on sodium valproate. According to NICE guidelines, which drug interaction is a key concern when co-prescribing sodium valproate?