Question

A 50-year-old with a history of chronic stable angina is started on sublingual glyceryl trinitrate. What advice should be given to avoid tolerance?

Accepted Answer

Have a nitrate-free interval of at least 8-12 hours each day

Answer

Use it around the clock at regular 6-hour intervals

Answer

Switch to oral isosorbide mononitrate for 24-hour coverage

Answer

Combine with a beta-blocker to prevent tolerance

Answer

Tolerance does not develop with glyceryl trinitrate

Practice question

A 50-year-old with a history of chronic stable angina is started on sublingual glyceryl trinitrate. What advice should be given to avoid tolerance?