Question

A 35-year-old woman has features suggestive of Cushing's syndrome: central obesity, purple striae, and proximal muscle weakness. Her 24-hour urinary free cortisol is elevated. According to NICE guidance, which test helps differentiate between ACTH-dependent and ACTH-independent Cushing's?

Accepted Answer

Plasma ACTH measurement

Answer

Low-dose dexamethasone suppression test

Answer

High-dose dexamethasone suppression test

Answer

Overnight dexamethasone suppression test

Answer

MRI of the adrenals

Practice question

A 35-year-old woman has features suggestive of Cushing's syndrome: central obesity, purple striae, and proximal muscle weakness. Her 24-hour urinary free cortisol is elevated. According to NICE guidance, which test helps differentiate between ACTH-dependent and ACTH-independent Cushing's?