Question

A patient with suspected coeliac disease has positive tissue transglutaminase (tTG) antibodies. According to NICE, which investigation is recommended next to confirm the diagnosis?

Accepted Answer

Upper GI endoscopy with duodenal biopsy

Answer

Trial of gluten-free diet for 4 weeks

Answer

Genetic testing (HLA-DQ2 or HLA-DQ8)

Answer

Faecal calprotectin

Answer

Anti-endomysial antibody test alone

Practice question

A patient with suspected coeliac disease has positive tissue transglutaminase (tTG) antibodies. According to NICE, which investigation is recommended next to confirm the diagnosis?