Vitamin B12 Deficiency

Investigation and treatment of B12 deficiency.

Reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner)
Last reviewed: 21 October 2025

Clinical Guidelines

CKS: Anaemia - B12 and folate deficiency
National
NICE guideline [NG239]
National
NICE guideline [NG239]: Vitamin B12 deficiency in over 16s: diagnosis and management
National
AAFP Clinical Practice Guideline: Vitamin B12 Deficiency: Recognition and Management
Local
CDC Guidance: Vitamin B12 Deficiency in Resettled Bhutanese Refugees
Local
Cobalamin (vitamin B12) Deficiency - Investigation & Management (British Columbia Guidelines)
Local
Diagnosis, Treatment and Long-Term Management of Vitamin B12 Deficiency in Adults: A Delphi Expert Consensus
Local
ESPEN micronutrient guideline
Local
ISPAD Clinical Practice Consensus Guidelines 2018: Other complications and associated conditions in children and adolescents with type 1 diabetes
Local
KDOQI Clinical Practice Guideline for Nutrition in CKD: 2020 Update
Local
NICE guideline [NG239]: Vitamin B12 deficiency in over 12s: diagnosis and management
Local