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Polypharmacy and Deprescribing

Managing multiple medications, particularly in older adults.

Reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner)
Last reviewed: 21 October 2025
GeriatricsPharmacologyGeneral Practice

Clinical Guidelines

NICE Medicines Optimisation NG5
National
Polypharmacy Guidance 2018
National
Italian guidelines on management of persons with multimorbidity and polypharmacy
Local
NICE guideline [NG56]: Multimorbidity: clinical assessment and management
Local

Recent iatroX Q&As

  • What criteria should I use to identify patients at risk of polypharmacy in my practice?Updated: 8/22/2025
  • How can I effectively assess the appropriateness of a patient's current medication regimen before considering deprescribing?Updated: 8/22/2025
  • What are the recommended strategies for safely deprescribing medications in older adults?Updated: 8/22/2025
  • How do I involve patients and their families in the decision-making process regarding deprescribing?Updated: 8/22/2025
  • What follow-up measures should I implement after deprescribing to monitor patient outcomes and medication adherence?Updated: 8/22/2025
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