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Knowledge Centre / Peptic Ulcer Disease

Peptic Ulcer Disease

Management of gastric and duodenal ulcers.

Reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner)
Last reviewed: 21 October 2025

Clinical Guidelines

BNF: Peptic ulcer disease
National
CKS: Dyspepsia - proven peptic ulcer
National
NICE guideline CG184: Dyspepsia and gastro-oesophageal reflux disease
National
SIGN guideline: Upper Gastrointestinal Bleeding
National
ACG Clinical Guideline: Treatment of Helicobacter pylori Infection
Local
Consensus conference. Medical treatment of peptic ulcer disease. Practice guidelines. Practice Parameters Committee of the American College of Gastroenterology
Local
Evidence-based clinical practice guidelines for peptic ulcer disease 2020 (Japanese Society of Gastroenterology)
Local
Practice Guidelines for Treatment of Peptic Ulcer Disease (JAMA)
Local
WSES Guidelines: Perforated and bleeding peptic ulcer
Local

Recent iatroX Q&As

  • What are the recommended first-line treatments for patients diagnosed with peptic ulcer disease?Updated: 8/14/2025
  • What investigations should be performed to confirm a diagnosis of peptic ulcer disease in primary care?Updated: 8/14/2025
  • When should I consider referring a patient with peptic ulcer disease for specialist evaluation?Updated: 8/14/2025
  • What lifestyle modifications should I advise to patients with peptic ulcer disease to aid in their management?Updated: 8/14/2025
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