HIV Post-Exposure Prophylaxis (PEP)

Guidelines for PEP after sexual or occupational exposure.

Reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner)
Last reviewed: 21 October 2025
Infectious DiseasesSexual Health

Clinical Guidelines

CKS: HIV infection and AIDS - Post-exposure prophylaxis
National
UK Guideline for the use of HIV Post-Exposure Prophylaxis 2021
National
WHO Guidelines for HIV post-exposure prophylaxis
National
2025 US Public Health Service Guidelines for the Management of Occupational Exposures to Human Immunodeficiency Virus and Recommendations for Postexposure Prophylaxis in Healthcare Settings
Local
BASHH PEPSE guidelines
Local
Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis
Local
Guidelines for HIV post-exposure prophylaxis
Local
Guidelines for the Emergency Management of Injuries (EMI) and Post Exposure Prophylaxis (PEP)
Local
HIV and AIDS: For health professionals - Canada.ca
Local
HIV Post-Exposure Prophylaxis (PEP) Guidelines – British Columbia Centre for Excellence in HIV/AIDS
Local
National HIV post-exposure prophylaxis (PEP) guidelines (Australia) - Fourth Edition
Local
PEP to Prevent HIV Infection - Clinical Guidelines Program
Local
Updated Guidelines for Antiretroviral Postexposure Prophylaxis After Sexual, Injection Drug Use, or Other Nonoccupational Exposure to HIV—United States, 2016
Local
Updated U.S. Public Health Service guidelines for the management of occupational exposures to HIV and recommendations for postexposure prophylaxis in healthcare settings
Local