Down's Syndrome

Overview and health monitoring.

Reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner)

Last reviewed: 21 October 2025

PaediatricsGenetics

Clinical Guidelines

CKS: Learning disabilities

Guidance for the assessment of children and young people with Down's syndrome

Health assessment of children and young people with Down's syndrome

ACOG Practice Bulletin No. 226: Screening for Fetal Chromosomal Abnormalities

ACOG Practice Bulletin No. 77: Screening for Fetal Chromosomal Abnormalities

Antenatal, Neonatal and Postnatal Care: Practitioners' Guide (Down's Syndrome Association, referencing NICE guidance)

Clinical Practice Guideline: Report of the Recommendations, Down Syndrome Assessment and Intervention

Down's Syndrome Health Assessment of Children and Young People (NHS Greater Glasgow and Clyde, based on DSMIG guidelines)

Down's Syndrome: Cardiac Disease: Congenital and Acquired (DSMIG Guideline, 2007)

Global Down Syndrome Foundation Medical Care Guidelines for Adults with Down Syndrome (2020)

Guidelines for the assessment of children and young people with Down's syndrome (NHS Scotland, 2022)

Health Supervision for Children and Adolescents With Down Syndrome (AAP Clinical Report, 2022)

Health Supervision for Children With Down Syndrome (AAP Clinical Report, 2011)

Medical Care of Adults With Down Syndrome: A Clinical Guideline (JAMA, 2020)

Society for Maternal-Fetal Medicine Consult Series #57: Evaluation and Management of Mosaic and Segmental Chromosomal Abnormalities

Supporting women and their partners through prenatal screening for Down's syndrome, Edwards' syndrome and Patau's syndrome (RCOG Consensus Guideline)