Alpha-1 Antitrypsin Deficiency

Overview and management.

Reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner)
Last reviewed: 21 October 2025
RespiratoryGastroenterology

Clinical Guidelines

European Respiratory Society statement: diagnosis and treatment of α1-antitrypsin deficiency
National
NICE guideline [NG101]
National
Alpha-1 antitrypsin deficiency (AATD). EASL Review, 2022
Local
Alpha-1 Antitrypsin Deficiency Clinical Practice Guidelines | Journal of COPD Foundation
Local
Alpha-1 Clinical Practice Guidelines - Alpha-1 Foundation
Local
Alpha-1-Antitrypsin Deficiency Targeted Testing and Augmentation Therapy: A Canadian Thoracic Society Clinical Practice Guideline
Local
Alpha-1-antitrypsin deficiency targeted testing and augmentation therapy: A Canadian Thoracic Society meta-analysis and clinical practice guideline
Local
American Thoracic Society/European Respiratory Society Statement: Standards for the Diagnosis and Management of Individuals with Alpha-1 Antitrypsin Deficiency
Local
European Respiratory Society statement: diagnosis and treatment of pulmonary disease in alpha-1 antitrypsin deficiency
Local
Portuguese consensus document for the management of alpha-1-antitrypsin deficiency
Local