OpenEvidence vs Epocrates (2025): Evidence vs Pharmacology

Last reviewed: 2025-12-19 · Reviewed by

At a Glance

Who is it for?

OpenEvidence:Clinicians

Epocrates:Prescribers

Why choose OpenEvidence?

  • **Scope**: Covers diagnosis, guidelines, and prognosis, not just drugs.
  • **Sources**: Cites clinical trials and papers.
  • **Context**: Can answer clinical questions involving multiple factors.

Why choose Epocrates?

  • **Safety**: The industry leader for interaction checking.
  • **Pill ID**: Visual identification tool.
  • **Formulary**: Shows insurance coverage (US).

Feature Comparison

CapabilityOpenEvidenceEpocrates
DomainMedicine (Broad)Pharmacology (Deep)
ToolAIDatabase

In-Depth Analysis

Overview

Epocrates is a safety tool. You use it before you sign the prescription to ensure you aren't making a mistake.

OpenEvidence is a decision tool. You use it before you decide to prescribe, to ensure you are choosing the right treatment.

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Use-Cases

Is this drug safe with Warfarin?

When to choose OpenEvidence

  • Can check papers, but less rigorous.

When to choose Epocrates

  • **Winner.** Definitive interaction check.

What is the latest trial on this drug?

When to choose OpenEvidence

  • **Winner.** Finds the recent evidence.

When to choose Epocrates

  • Only shows the approved label info.